The complement system is a major pillar of the humoral innate immune system. As a first line of defense against pathogens, it mediates early inflammatory response and links different branches of ...

The classical complement pathway is an important effector mechanism for clearance of infections, which is also employed in immunotherapies to eliminate tumor cells. Its initiation is governed by the ...

Complement potentiates various forms of cancer therapy, including antibody-mediated cytotoxicity, vaccines and radiotherapy. Complement-dependent cytotoxicity can be improved by optimizing antibody ...

The complement cascade was identified over 100 years ago, yet investigation of its role in pregnancy remains an area of intense research. Complement inhibitors at the maternal-fetal interface prevent ...

Copyright: Published by Elsevier Ltd. The complement system is recognised as a protector against blood-borne pathogens and a controller of immune system and tissue ...

The complement system consists of several complement proteins synthesized by the liver’s Kupffer cells and subsequently found in the body’s blood and tissues. The proteins themselves are both zymogens ...

Complement 3 glomerulopathy (C3G) is a rare kidney disease that affects your body’s innate immune system (complement system). Complement 3 glomerulopathy (C3G) is a kidney disease that’s caused by ...