The tagged microarray marker (TAM) method allows high-throughput differentiation between predicted alternative PCR products. Typically, the method is used as a molecular marker approach to determining ...

Identification of the cellular targets of small-molecule hits in phenotypic screens is a central challenge in the development of small molecules as biological tools and potential therapeutics. To ...

High-throughput RNAi screening is widely applied in biological research, but remains expensive, infrastructure-intensive and conversion of many assays to HTS applications in microplate format is not ...

Genotoxins cause DNA damage, which can result in genomic instability. The genetic changes induced have far-reaching consequences, often leading to diseases such as cancer. A wide range of genotoxins ...

Resequencing DNA microarray (RMA) technology uses probes designed to identify a panel of viral sequences. It can be used for detecting emerging viruses by revealing the nucleotide polymorphisms within ...

Abstract: Microarray image gridding is one important step of microarray image analysis to determine 2D image coordinates of all array spots in the hybridized gene chip image. Accuracy of microarray ...

We developed a microarray-based system for screening small molecules in mammalian cells. This system is compatible with image-based screens and requires fewer than 100 cells per compound. Each ...

RNA interference technology, which is used in cell biology, has revolutionized functional research of the gene products in the last ten years. Now researchers have developed a method which allows a ...

A method of analyzing DNA microarray data based on the physical modeling of hybridization is presented. We demonstrate, in experimental data, a correlation between observed hybridization intensity and ...

Division of Biology, OSEL/CDRH/FDA. Tuberculosis is the second leading cause of adult mortality among infectious diseases and is responsible for about 2 million deaths per year worldwide. The World ...

Abstract: Microarray techniques have revolutionized genomic research by making it possible to monitor the expression of thousands of genes in parallel. Data clustering analysis has been extensively ...