The randomized ISAT demonstrated the superiority of endovascular treatment in patients with ruptured intracranial aneurysms considered suitable for either clipping or coiling. A later publication ...

Phase II trial designs that ignore between-patient heterogeneity and do not allow for treatment-subgroup interactions may produce very large false positive and false ...

We review Bayesian and Bayesian decision theoretic approaches to subgroup analysis and applications to subgroup-based adaptive clinical trial designs. Subgroup analysis refers to inference about ...

Objective To investigate the credibility of authors’ claims of subgroup effects using a representative sample of recently published randomised controlled trials. Design Systematic review. Data source ...

Two Bayesian clinical trial designs that perform subgroup-specific decision making and inference based on elicited utilities of patient outcomes are reviewed. The first is a randomized comparative ...

2 Center for Clinical Epidemiology and Evidence-Based Medicine, West China Hospital, Sichuan University, Chengdu, China 3 Basel Institute for Clinical Epidemiology and Biostatistics, University ...

The values of the subgroup-variable, which is specified in the chart statement, indicate how the observations in the input data set (a DATA=, HISTORY=, or TABLE= data set) are arranged into rational ...

1 Department of Neurology, Loyola University Medical Center, Maywood, CA, United States 2 Department of Pharmacy, Loyola University Medical Center, Maywood, CA, United States The use of high-dose ...

This example illustrates how to compute and display control limits for the maximum of a subgroup sample. Subgroup samples of 20 metal braces are collected daily, and the lengths of the braces are ...